In Vivo Genotoxicity
In vivo genotoxicity tests can be used when obtaining in vitro positive results which can reflect absorption, metabolism, distribution and excretion of chemicals. Compared with in vitro genotoxicity assay, in vivo genotoxicity assay has been used to verify in vitro assay result and definitely provide biological significance for certain organs and cell types.
In Vivo Genotoxicity Assays at Creative Animodel
We provide a portfolio of in vivo genotoxicity assay services which can be chosen and customized to meet your specific needs. Our in vivo genotoxicity assays are considered as powerful tools to distinguish between genotoxic carcinogens and non-genotoxic carcinogens as well as to identify carcinogens and mutagens. Our services include but are not limited to:
In Vivo Rodent Micronucleus TestIn vivo micronucleus assays using rodent haematopoietic cells from bone marrow or peripheral blood are widely used for the assessment of clastogenicity and aneugenicity of chemicals.In Vivo Pig-a AssayThis assay is used for scoring the frequency of mutant phenotype erythrocytes and mutant phenotype immature erythrocytes by measuring the induction of mutations at the Pig-a gene.Big Blue® Transgenic Rodent Mutation AssayThe assay is based on lacl transgenic (Big Blue®) rats and mice that contain multiple copies of chromosomally integrated plasmid and phage shuttle vectors with reporter genes to detect mutation.
Creative Animodel has developed a package of in vivo genotoxicity services for drug discovery programs. Our genotoxicity services are designed and performed by experienced experts. If you have any needs, please feel free to contact us.
1. Kang S H, et al. Recent Advances in In Vivo Genotoxicity Testing: Prediction of Carcinogenic Potential Using Comet and Micronucleus Assay in Animal Models. Journal of Cancer Prevention. 2013, 18(4):277-288.