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In Vivo Genotoxicity

In vivo genotoxicity tests can be used when obtaining in vitro positive results which can reflect absorption, metabolism, distribution and excretion of chemicals. Compared with in vitro genotoxicity assay, in vivo genotoxicity assay has been used to verify in vitro assay result and definitely provide biological significance for certain organs and cell types.

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The in vitro assays have been considered as the genotoxicity tests for screening substances (e.g. drug candidates, chemical substances, medicinal plant extract, etc.) and evaluating their initial safety while the in vivo assays provide detailed information of biological and physiological significance. They can determine whether any potential mutagenic effects that have shown in the in vitro step have appeared again in the animal’s whole physiological system. Consequently, the in vivo assays have been known as important processes in the verification of in vitro test and risk assessments for humans, demonstrating that they have more impact than in vitro assays.

In Vivo Genotoxicity Assays at Creative Animodel

We provide a portfolio of in vivo genotoxicity assay services which can be chosen and customized to meet your specific needs. Our in vivo genotoxicity assays are considered as powerful tools to distinguish between genotoxic carcinogens and non-genotoxic carcinogens as well as to identify carcinogens and mutagens. Our services include but are not limited to:
In Vivo Rodent Micronucleus TestIn vivo micronucleus assays using rodent haematopoietic cells from bone marrow or peripheral blood are widely used for the assessment of clastogenicity and aneugenicity of chemicals.In Vivo Pig-a AssayThis assay is used for scoring the frequency of mutant phenotype erythrocytes and mutant phenotype immature erythrocytes by measuring the induction of mutations at the Pig-a gene.Big Blue® Transgenic Rodent Mutation AssayThe assay is based on lacl transgenic (Big Blue®) rats and mice that contain multiple copies of chromosomally integrated plasmid and phage shuttle vectors with reporter genes to detect mutation.

Creative Animodel has developed a package of in vivo genotoxicity services for drug discovery programs. Our genotoxicity services are designed and performed by experienced experts. If you have any needs, please feel free to contact us.

1. Kang S H, et al. Recent Advances in In Vivo Genotoxicity Testing: Prediction of Carcinogenic Potential Using Comet and Micronucleus Assay in Animal Models. Journal of Cancer Prevention. 2013, 18(4):277-288.

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