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In Vivo Immunotoxicity

The major function of the immune system is to provide host integrity and to ensure appropriate function of organs and tissues. To accomplish this, it must be able to distinguish self from non-self and be able to assess tissue-specific cell status and function. As a fully dispersed system, it is represented in most tissues, organs and peripheral sites (e.g. respiratory, dermal, gastrointestinal, neurological, cardiovascular, reproductive, hepatic and endocrine). That's to say, the immune system presents a readily accessible toxicological target regardless of the route of hazardous substance exposure.

Therefore, from a risk assessment perspective, the issue is not related to whether immune exposure occurs following a hazardous substance exposure, but related to whether a given exposure is likely to produce an adverse immunotoxic outcome among susceptible populations, such as an altered immune function that may increase incidence or severity of infectious diseases or cancer.

Immunotoxicity Researches at Creative Animodel

Creative Animodel has years of experience in immunotoxicity, the research services involve:
1) The parameters that should be routinely assessed in toxicology studies to determine effects of a drug on immune function;
2) Evaluate whether additional immunotoxicity studies should be conducted;
3) Characterize the significance of a given drug’s effect on the immune system.

Indicators Detected at Creative Animodel

Complete blood count and differential white blood cell countLymphoid organ weights, body weight and temperatureHistopathology, gross and microscopic examination of spleen, thymus, lymph nodes, Peyer’s patches and bone marrow
Humoral Immunity
Total serum protein, albumin, globulin ratioImmunoglobulin isotype distribution of IgM, IgG, IgA and IgETotal haemolytic complement activitySerum auto-antibody screen and deposition of immunoglobulins
Cell-Mediated Immunity
Immuno-staining and flow-cytometric quantitation of spleen and lymph nodes for B cells and CD4+/CD8+ T cellsMitogen stimulation assays for B and T cells (spleen)Quantitation of resident peritoneal cells and phagocytic ability

Creative Animodel has earned a great reputation worldwide with our genius services. Our high-quality services are supportive for your research, including improving the efficiency, saving time and expense, also decreasing the incidence of mistake. As a good assistant for you to discover and develop the new drug, we are looking forward to working with you side by side.

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Creative Animodel

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