45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-207-8356 1-631-871-5806

Toxicology

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Nephrotoxicity

Creative Animodel is specialized in providing an integrated list of excellent in vitro toxicity assays to detect renal toxicity of drug candidates at an early stage. With standard and custom assays, we focus on providing our global clients with high-quality, cost-effective, and reproducible data and flexible solutions with a fast turnaround time.

The Overview of Nephrotoxicity

The kidney is an integral part of the body to perform several vital functions including the maintenance of homeostasis and regulation of the extracellular environment, such as detoxification, and excretion of drug and metabolites. Therefore, the kidney is regarded as a major target organ for exogenous toxicants. The general mechanisms that induce nephrotoxicity involve changes in glomerular hemodynamics, inflammation, tubular cell toxicity, crystal nephropathy, rhabdomyolysis, and thrombotic microangiopathy.

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Approximately 20% of nephrotoxicity is caused by drugs. But when it comes to the elderly, the incidence of nephrotoxicity increases to 66% as the average life span increases. Anticancer medicine and chemotherapy are of limited use in view of nephrotoxicity. Drug-induced nephrotoxicity is increasingly considered as a prominent contributor to kidney disease, including acute kidney injury (AKI) and chronic kidney disease (CKD). Therefore, the issue of drug-induced nephrotoxicity should never be overstated.

Nephrotoxicity Assays at Creative Animodel

We conduct qualified in vitro cell-based nephrotoxicity assays during lead optimization to determine the potential renal toxicity of the test compound.

Tubule Epithelial Cell Toxicity
We offer an effective in vitro cell-based screening model to evaluate potential nephrotoxicity. Both primary human renal proximal tubule epithelial cells and human renal proximal tubule epithelial cell line (HK-2) are available.
Functional Nephrotoxicity Assays
Key marks of drug-induced renal injury include cytolytic activity and lysosomal phospholipid accumulation. We have developed three automated nephrotoxicity assays to identify nephrotoxic compounds at an early stage, including lysosomal activity assay, mitochondrial toxicity assay, and kinetic cytolysis assay.

Our Advantages

• The most comprehensive portfolio of automated assays
• Pre-validated human renal proximal tubule epithelial cells
• High Content Analysis
• Low compound requirement
• Under GLP and GMP guidelines
• In compliance with FDA and EPA regulations

Creative Animodel performs a wide spectrum of in vitro toxicity tests and assays complying with FDA and EPA regulations. With state-of-the-art facilities and profound pharmaceutical knowledge, we are capable to perform cell-based assays to facilitate pharmaceutical product development. We look forward to the collaboration with you in the near future.

Reference:
1. Kim, S.Y.; Moon, A. Drug-induced nephrotoxicity and its biomarkers. Biomolecules & Therapeutics. 2012, 20(3): 268.

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45-1 Ramsey Road, Shirley, NY 11967, USA 1-631-207-8356 1-631-871-5806 Europe 44-207-097-1828

Creative Animodel

Creative Animodel is a world's leading commercial provider of custom animal model services. We offer top-quality services at unbeatable prices. Our customer service representatives are available 24 hours a day, from Monday to Sunday.

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