Drug metabolism and pharmacokinetics (DMPK) is the study of drug disposition process in the organism, which use mathematics and dynamics models to describe the process of absorption, distribution, metabolism and excretion (ADME), then combining the exposure of drugs in blood circulation and target organs with clinical manifestations. In order to reduce the clinical failure due to poor PK characters, there have been considerable efforts put into developing in vitro, in vivo and in silico approaches to screening candidates for various DMPK properties.
Toxicology and Safety Assessment
In the area of toxicology, Creative Animodel offers our customers standard protocols designed to support drug approval submissions to domestic and international regulatory agencies.
We offer a wide range of in vitro toxicology assays based on cell and zebrafish system, including hepatotoxicity, cardiotoxicity, neurotoxicity, nephrotoxicity, and genotoxicity.
Drug-drug interactions (DDI) refer to simultaneously administered drugs that interfere with each other's absorption, distribution, metabolism, and elimination (ADME).
Safety pharmacology studies are designed to assess the acute and potentially life-threatening risks of your products on mammalian species.